diff --git a/configure b/configure
index 197e978a55..3e9222ed1b 100755
--- a/configure
+++ b/configure
@@ -6796,10 +6796,17 @@ check_deps $CONFIG_LIST       \
 enabled threads && ! enabled pthreads && ! enabled atomics_native && die "non pthread threading without atomics not supported, try adding --enable-pthreads or --cpu=i486 or higher if you are on x86"
 enabled avresample && warn "Building with deprecated library libavresample"
 
-if test $target_os = "haiku"; then
+case $target_os in
+haiku)
     disable memalign
     disable posix_memalign
-fi
+    ;;
+*-dos|freedos|opendos)
+    if test_cpp_condition sys/version.h "defined(__DJGPP__) && __DJGPP__ == 2 && __DJGPP_MINOR__ == 5"; then
+        disable memalign
+    fi
+    ;;
+esac
 
 flatten_extralibs(){
     nested_entries=