diff --git a/libavutil/mips/intreadwrite.h b/libavutil/mips/intreadwrite.h
index 9ba0491372..32084f68f6 100644
--- a/libavutil/mips/intreadwrite.h
+++ b/libavutil/mips/intreadwrite.h
@@ -24,7 +24,7 @@
 #include <stdint.h>
 #include "config.h"
 
-#if ARCH_MIPS64 && HAVE_INLINE_ASM
+#if ARCH_MIPS64 && HAVE_INLINE_ASM && !HAVE_MIPS64R6
 
 #define AV_RN32 AV_RN32
 static av_always_inline uint32_t AV_RN32(const void *p)
@@ -41,6 +41,6 @@ static av_always_inline uint32_t AV_RN32(const void *p)
     return v;
 }
 
-#endif /* ARCH_MIPS64 && HAVE_INLINE_ASM */
+#endif /* ARCH_MIPS64 && HAVE_INLINE_ASM && !HAVE_MIPS64R6 */
 
 #endif /* AVUTIL_MIPS_INTREADWRITE_H */