diff --git a/configure b/configure
index 26a58ff6e5..eec43c3b06 100755
--- a/configure
+++ b/configure
@@ -482,6 +482,7 @@ Developer options (useful when working on FFmpeg itself):
   --ignore-tests=TESTS     comma-separated list (without "fate-" prefix
                            in the name) of tests whose result is ignored
   --enable-linux-perf      enable Linux Performance Monitor API
+  --disable-large-tests    disable tests that use a large amount of memory
 
 NOTE: Object files are built at the place where configure is launched.
 EOF
@@ -1931,6 +1932,7 @@ CONFIG_LIST="
     $SUBSYSTEM_LIST
     autodetect
     fontconfig
+    large_tests
     linux_perf
     memory_poisoning
     neon_clobber_test
@@ -3727,6 +3729,7 @@ enable asm
 enable debug
 enable doc
 enable faan faandct faanidct
+enable large_tests
 enable optimizations
 enable runtime_cpudetect
 enable safe_bitstream_reader
diff --git a/tests/Makefile b/tests/Makefile
index 0ef571b067..e5f41008d4 100644
--- a/tests/Makefile
+++ b/tests/Makefile
@@ -85,6 +85,16 @@ FILTERDEMDECENCMUX = $(call ALLYES, $(1:%=%_FILTER) $(2)_DEMUXER $(3)_DECODER $(
 
 PARSERDEMDEC       = $(call ALLYES, $(1)_PARSER $(2)_DEMUXER $(3)_DECODER)
 
+# Allow overriding CONFIG_LARGE_TESTS via LARGE_TESTS, if set on the
+# make command line.
+ifeq ($(LARGE_TESTS), yes)
+CONFIG_LARGE_TESTS:=yes
+!CONFIG_LARGE_TESTS:=
+else ifeq ($(LARGE_TESTS), no)
+CONFIG_LARGE_TESTS:=
+!CONFIG_LARGE_TESTS:=yes
+endif
+
 include $(SRC_PATH)/$(APITESTSDIR)/Makefile
 include $(SRC_PATH)/$(DNNTESTSDIR)/Makefile
 
diff --git a/tests/fate/seek.mak b/tests/fate/seek.mak
index 04f54ee6c4..98d2b54674 100644
--- a/tests/fate/seek.mak
+++ b/tests/fate/seek.mak
@@ -64,7 +64,6 @@ FATE_SEEK_VSYNTH_LENA-$(call ENCDEC, ASV1,          AVI)     += asv1
 FATE_SEEK_VSYNTH_LENA-$(call ENCDEC, ASV2,          AVI)     += asv2
 FATE_SEEK_VSYNTH_LENA-$(call ENCDEC, DNXHD,         DNXHD)   += dnxhd-720p
 FATE_SEEK_VSYNTH_LENA-$(call ENCDEC, DNXHD,         DNXHD)   += dnxhd-720p-rd
-FATE_SEEK_VSYNTH_LENA-$(call ENCDEC, DNXHD,         DNXHD)   += dnxhd-4k-hr-lb
 FATE_SEEK_VSYNTH_LENA-$(call ENCDEC, DNXHD,         MOV)     += dnxhd-1080i
 FATE_SEEK_VSYNTH_LENA-$(call ENCDEC, DVVIDEO,       DV)      += dv
 FATE_SEEK_VSYNTH_LENA-$(call ENCDEC, DVVIDEO,       DV)      += dv-411
@@ -80,6 +79,8 @@ FATE_SEEK_VSYNTH_LENA-$(call ENCDEC, JPEGLS,        AVI)     += jpegls
 FATE_SEEK_VSYNTH_LENA-$(call ENCDEC, LJPEG MJPEG,   AVI)     += ljpeg
 FATE_SEEK_VSYNTH_LENA-$(call ENCDEC, MJPEG,         AVI)     += mjpeg
 
+FATE_SEEK_VSYNTH_LENA-$(call ALLYES, DNXHD_ENCODER DNXHD_DECODER LARGE_TESTS) += dnxhd-4k-hr-lb
+
 FATE_SEEK_VSYNTH_LENA-$(call ENCDEC, MPEG1VIDEO, MPEG1VIDEO MPEGVIDEO) +=    \
                                                     mpeg1                    \
                                                     mpeg1b
diff --git a/tests/fate/vcodec.mak b/tests/fate/vcodec.mak
index 452246689e..fc27da5456 100644
--- a/tests/fate/vcodec.mak
+++ b/tests/fate/vcodec.mak
@@ -29,13 +29,14 @@ FATE_VCODEC-$(call ENCDEC, DNXHD, DNXHD) += dnxhd-720p                  \
                                             dnxhd-720p-rd               \
                                             dnxhd-720p-10bit            \
                                             dnxhd-720p-hr-lb            \
-                                            dnxhd-4k-hr-lb              \
                                             dnxhd-uhd-hr-sq             \
-                                            dnxhd-2k-hr-hq              \
                                             dnxhd-edge1-hr              \
                                             dnxhd-edge2-hr              \
                                             dnxhd-edge3-hr
 
+FATE_VCODEC-$(call ALLYES, DNXHD_ENCODER DNXHD_DECODER LARGE_TESTS) += dnxhd-4k-hr-lb \
+                                                                       dnxhd-2k-hr-hq
+
 FATE_VCODEC-$(call ENCDEC, VC2 DIRAC, MOV) += vc2-420p vc2-420p10 vc2-420p12 \
                                               vc2-422p vc2-422p10 vc2-422p12 \
                                               vc2-444p vc2-444p10 vc2-444p12 \